NCKU, 生理學科暨研究所

NCKU, 生理學科暨研究所

莊季瑛 教授兼所長

莊季瑛(Jih-Ing Chuang)教授

 

學經歷:

師範大學 學士,1976-1981

台灣大學 碩士,1981-1983

高雄醫學大學 博士,1988-1993

成大生理所 助教,1985-1987

成大生理所 講師,1987-1996

成大生理所 副教授,1996-2004

成大生理所 教授,2004-present

成大生理所 所長,2009-2012

成大生理所 所長,2015-present

專長學科

神經退化性疾病、神經科學、自由基生物學

獎勵事項

 

E-mail

jichuang@mail.ncku.edu.tw

辦公室

82-0719 分機:5460

實驗室

82-0754 分機:5447

嗜好:烘培園藝,運動

研究方向及興趣:

1. 探討神經滋養因子與抗氧化防禦系統的相互作用。

2. 探討保護神經細胞的作用機制,以利於治療或預防神經退化性疾病的藥物研發。

3. 探討腦溫對大腦功能的影響

4. 探討多巴胺神經細胞分化與新生及其在神經退化性疾病的影響

實驗室成員:

現在成員

博士班:

碩士班:鐘悅慈(碩二)、郭瑀涵(碩一)

 

過去成員

博士班:

碩士班:謝嘉芸(2015)、石靜婷(2012)、黃秋瑛(2012

相關著作(PubMed連結)

1.         Chuang JI*, Huang JY, Tsai SJ, Sun HS, Yang SH, Chuang PC, Huang BM, Ching CH. FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free Rad Biol Med, 2015, 89:274-286.

2.         Tsou YH, Shih CT, Ching CH, Huang JY, Jen CJ, Yu L, Kuo YM, Wu FS, Chuang JI*. Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity. Exp Neurol, 2015, 263:50-62.

3.         Tsai MC, Chen WJ, Tsai MS, Ching CH, and Chuang JI* Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats. J Pineal Res, 2011, 51:233-245.

4.         Wu SY, Wang TF, Yu L, Jen CJ, Chuang JI, Wu FS, Wu CW, Kuo YM. Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain Behav Immunity, 2011, 25:135-146.

5.         Huang TY, Lin LS, Cho KC, Chen S, Kuo YM, Yu L, Wu FS, Chuang JI, Chen HI, Jen CJ. Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellum. J Appl Physiol 113: 889-895, 2012.

6.         Lin TW, Chen SJ, Huang TY, Chang CY, Chuang JI, Wu FS, Kuo YM, Jen CJ. Different types of exercise induce differential effects on neuronal adaptations and memory performance. Neurobiol Learn & Memory, 97:140-147, 2012.

7.         Huang JY, Chuang JI*.  Fibroblast growth factor 9 upregulates heme oxygenase-1 and γ-glutamylcysteine synthetase expression to protect neurons from 1-methyl-4-phenylpyridinium toxicity. Free Rad Biol Med, 2010, 49:1099-1108.

8.         Huang JY, Hong YT, Chuang JI*. Fibroblast growth factor 9 prevents MPP+-induced death of dopaminergic neurons and is involved in melatonin neuroprotection in vivo and in vitro. J Neurochem, 109:1400-1412, 2009.

9.         Lin CH, Huang JY, Ching CH and Chuang JI*. Melatonin reduces the neuronal loss, down regulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. J Pineal Res, 44:205-213, 2008.

實驗室特色連結

實驗室活動照片連結