NCKU, 生理學科暨研究所

NCKU, 生理學科暨研究所

蔡少正 特聘教授

蔡少正(Shaw-Jenq Tsai)特聘教授

學經歷:

成功大學 學士,1982-1986

美國東密西根大學 碩士,1990-1992

美國威斯康辛大學 博士,1993-1997

美國威斯康辛大學 博士後研究,1997-1998

成大生理所 助理教授,1998-2002

成大生理所 副教授,2002-2005

成大生理所 教授,2005-迄今

成大生理所 教授兼所長,2006-2009

成大生理所 特聘教授,2008-迄今
美國休士頓貝勒醫學院 訪問教授,2010-2011

成功大學生物資訊中心 負責人,2001-迄今

科技部生命科學司 司長,2014-迄今

專長學科

轉譯醫學、生物資訊、細胞生物學、表觀遺傳學、子宮內膜異位症

獎勵事項
美國實驗生物醫學協會(Societyfor Experimental Biology and MedicineSEBM2014年傑出科學家獎 (Outstanding Scientist Award)

E-mail

seantsai@mail.ncku.edu.tw

辦公室

82-0701 分機:5426

實驗室

82-0734 分機:5429

嗜好:任何活的東西

研究方向及興趣:

本實驗室主要有三個研究方向:
一、缺氧誘導因子(HIF-1α)調控基因與癌症抗藥性之研究。細胞因為缺氧會產生種種不同的生理反應或病理變化,包括學習記憶、癌症、心血管疾病、生長遲緩、腦部疾病、肺部疾病等。我們利用生物資訊學的方法,將基因體中會受缺氧誘導因子調控之基因(包括人類、大鼠、小鼠)找尋出來,並研究其在生理、病理上的功能,尤其著重在癌症抗藥性方面的探討,目前以大腸癌及胰臟癌的抗藥性機制為重點
二、研究整個基因體的調控(Gene regulatory network)及細胞分化、去分化及再分化的機轉。表觀基因體調控(epigenomic modification and reprograming)對細胞之命運影響至巨,甚或造成細胞病變。我們利用生物資訊學、功能性基因體學、系統生物學等尖端方法,對此一現象作深入的研究
三、探討子宮內膜異位 (endometriosis)成因之分子機制,子宮內膜異位症約佔生殖年齡期婦女人數的10-15%,大部分會導致不孕症的發生,目前有關子宮內膜異位形成之原因,並不清楚。本實驗室過去十幾年的研究,在這個領域已有相當傑出的成果,居於世界領先地位,未來將著重在整合性基因功能上的研究,期盼能發展出可以治療這個疾病的方法或藥物。

實驗室成員:

現在成員

助理:黃美鳳(2001)、賴嬿羽(2003)、葉憶萱(2008)、湯宜禎(2013)、洪淑貞(2014)、張寧(2015)、傅兆麟(2016)

博士後研究:蕭貴陽(2012)、林世杰(2012)、王竹安(2014)

博士班:侯沛琪(99)、李脩琦(101)、李婉寧(105
碩士班:陳思瑜(103)陳一誠(104)、葛宇庭(105)、戴昱菁(105)

過去成員

助理:莊佩錦、葉惠群、蕭貴陽、林世杰、王竹安(2005)、廖晨喻、簡郡緯、王致權、曹碧華(2010)

博士後研究:莊佩錦()、庄司豊(2004)、呂淳雯()、林世杰(2011)、廖婉玲(2013)

博士班:吳孟興(89)、莊佩錦(91)、林世杰(96)、呂淳雯(93)、簡郡緯(98)、林劭潔、李祐華(100)

碩士班:莊佩錦(87)、林晨鐘(88)、蕭貴陽(89)、許智超(90)、陳克帆(91)、林世杰(91)、王竹安(91)、蔡秀真(92)、呂淳雯(92)、吳軍緯(93)、郭瓊茵(93)、簡郡緯(94)、古士宜(94)、李脩琦(98)、張于凡(98)、李祐華(99)、黃詩雅(99)、林怡岑(99)、蔡佳玲(100)、張寧(101)、傅兆麟(102)、張以恆(103)、徐敬庭(103)

大學部:林晨鐘(1998)、蕭貴陽(1999)、陳秀梅(P)(1999)、林世杰(2000)、陳克帆(2000)、吳孟輯(2002)、陳宥芳(2002)、蔡宗翰(2003)、黃智群(2006)、張雅嵐(2006)、李祐華(2006)

相關著作(PubMed連結)

  • Lin, S. C., Kao, C. Y., Lee, H. J., Creighton, C. J., Ittmann, M. M., Tsai, S. J., Tsai, S. Y., and Tsai, M. J. (2016) Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun 7, 11418 PMID:27108958
  • Lai, M. S., Wang, C. Y., Yang, S. H., Wu, C. C., Sun, H. S., Tsai, S. J., Chuang, J. I., Chen, Y. C., and Huang, B. M. (2016) The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes. Organogenesis 12, 61-77 PMID:27078042
  • Chien, C. W., Hou, P. C., Wu, H. C., Chang, Y. L., Lin, S. C., Lin, S. C., Lin, B. W., Lee, J. C., Chang, Y. J., Sun, H. S., and Tsai, S. J. (2016) Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. Oncogene PMID:27132510
  • Wang, C. A., and Tsai, S. J. (2015) The non-canonical role of vascular endothelial growth factor-C axis in cancer progression. Exp Biol Med (Maywood) 240, 718-724 PMID:25888649
  • Liang, K. C., Tseng, J. T., Tsai, S. J., and Sun, H. S. (2015) Characterization and distribution of repetitive elements in association with genes in the human genome. Comput Biol Chem 57, 29-38 PMID:25748288
  • Hsiao, K. Y., Wu, M. H., Chang, N., Yang, S. H., Wu, C. W., Sun, H. S., and Tsai, S. J. (2015) Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis. Mol Hum Reprod 21, 894-904 PMID:26433194
  • Hsiao, K. Y., Lin, S. C., Wu, M. H., and Tsai, S. J. (2015) Pathological functions of hypoxia in endometriosis. Front Biosci (Elite Ed) 7, 309-321 PMID:25553382
  • Fu, M. H., Li, C. L., Lin, H. L., Tsai, S. J., Lai, Y. Y., Chang, Y. F., Cheng, P. H., Chen, C. M., and Yang, S. H. (2015) The Potential Regulatory Mechanisms of miR-196a in Huntington's Disease through Bioinformatic Analyses. PLoS One 10, e0137637 PMID:26376480
  • Chuang, J. I., Huang, J. Y., Tsai, S. J., Sun, H. S., Yang, S. H., Chuang, P. C., Huang, B. M., and Ching, C. H. (2015) FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free Radic Biol Med 89, 274-286 PMID:26424114
  • Tang, Y. T., Kao, H. Y., Tsai, S. J., and Wang, H. C. (2014) A semi-supervised, weighted pattern-learning approach for extraction of gene regulation relationships from scientific literature. Int J Data Min Bioinform 9, 401-416 PMID:25757247
  • Lin, S. C., Liao, W. L., Lee, J. C., and Tsai, S. J. (2014) Hypoxia-regulated gene network in drug resistance and cancer progression. Exp Biol Med (Maywood) 239, 779-792 PMID:24812122
  • Lin, S. C., Li, Y. H., Wu, M. H., Chang, Y. F., Lee, D. K., Tsai, S. Y., Tsai, M. J., and Tsai, S. J. (2014) Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. J Clin Endocrinol Metab 99, E427-437 PMID:24423359
  • Liao, W.-L., Lin, S.-C., Sunny Sun, H., and Tsai, S. J. (2014) Hypoxia-induced tumor malignancy and drug resistance: Role of microRNAs. Biomarkers and Genomic Medicine 6, 1-11 http://dx.doi.org/10.1016/j.bgm.2014.01.003
  • Lai, M. S., Cheng, Y. S., Chen, P. R., Tsai, S. J., and Huang, B. M. (2014) Fibroblast growth factor 9 activates akt and MAPK pathways to stimulate steroidogenesis in mouse leydig cells. PLoS One 9, e90243 PMID:24603862
  • Chen, T. M., Shih, Y. H., Tseng, J. T., Lai, M. C., Wu, C. H., Li, Y. H., Tsai, S. J., and Sun, H. S. (2014) Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation. Nucleic Acids Res 42, 2932-2944 PMID:24334956
  • Wu, S. P., Cheng, C. M., Lanz, R. B., Wang, T., Respress, J. L., Ather, S., Chen, W., Tsai, S. J., Wehrens, X. H., Tsai, M. J., and Tsai, S. Y. (2013) Atrial identity is determined by a COUP-TFII regulatory network. Developmental cell 25, 417-426 http://dx.doi.org/10.1016/j.devcel.2013.04.017
  • Wu, M. H., Chuang, P. C., Lin, Y. J., and Tsai, S. J. (2013) Suppression of annexin A2 by prostaglandin E(2) impairs phagocytic ability of peritoneal macrophages in women with endometriosis. Hum Reprod 28, 1045-1053 PMID:23340055
  • Wang, H. C., Kooi, T. K., Kao, H. Y., Lin, S. C., and Tsai, S. J. (2013) Using positive and negative patterns to extract information from journal articles regarding the regulation of a target gene by a transcription factor. Comput Biol Med 43, 2214-2221 PMID:24290938
  • Qin, J., Wu, S. P., Creighton, C. J., Dai, F., Xie, X., Cheng, C. M., Frolov, A., Ayala, G., Lin, X., Feng, X. H., Ittmann, M. M., Tsai, S. J., Tsai, M. J., and Tsai, S. Y. (2013) COUP-TFII inhibits TGF-beta-induced growth barrier to promote prostate tumorigenesis. Nature 493, 236-240 PMID:23201680
  • Lai, M. C., Wang, S. W., Cheng, L., Tarn, W. Y., Tsai, S. J., and Sun, H. S. (2013) Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation. PLoS One 8, e68665 PMID:23840900
  • Cheng, P. H., Li, C. L., Chang, Y. F., Tsai, S. J., Lai, Y. Y., Chan, A. W., Chen, C. M., and Yang, S. H. (2013) miR-196a ameliorates phenotypes of Huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models. Am J Hum Genet 93, 306-312 PMID:23810380
  • Chen, J. S., Hung, W. S., Chan, H. H., Tsai, S. J., and Sun, H. S. (2013) In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics 29, 420-427 PMID:23267173
  • Chen, H. M., Lin, Y. H., Cheng, Y. M., Wing, L. Y., and Tsai, S. J. (2013) Overexpression of integrin-beta1 in leiomyoma promotes cell spreading and proliferation. J Clin Endocrinol Metab 98, E837-846 PMID:23482612
  • Wu, M. H., Lu, C. W., Chang, F. M., and Tsai, S. J. (2012) Estrogen receptor expression affected by hypoxia inducible factor-1alpha in stromal cells from patients with endometriosis. Taiwan J Obstet Gynecol 51, 50-54 http://dx.doi.org/10.1016/j.tjog.2012.01.010
  • Wiltbank, M. C., Salih, S. M., Atli, M. O., Luo, W., Bormann, C. L., Ottobre, J. S., Vezina, C. M., Mehta, V., Diaz, F. J., Tsai, S. J., and Sartori, R. (2012) Comparison of endocrine and cellular mechanisms regulating the corpus luteum of primates and ruminants. Animal reproduction / Colegio Brasileiro de Reproducao Animal 9, 242-259
  • Wang, C. C., Lin, S. C., Lee, Y. H., and Tsai, S.J. (2012) Hypoxia-Induced Tumor Progression and Drug Resistance: From Current Understandings to Future Perspectives. Adaptive Medicine 4, 132-144 DOI:10.4247/AM.2012.ABC033
  • Lin, S. C., Wang, C. C., Wu, M. H., Yang, S. H., Li, Y. H., and Tsai, S. J. (2012) Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. J Clin Endocrinol Metab 97, E1515-1523 PMID:22648654
  • Lin, M. W., Tsai, S. J., Chou, P. Y., Huang, M. F., Sun, H. S., and Wu, M. H. (2012) Vitamin D receptor 1a promotor -1521 G/C and -1012 A/G polymorphisms in polycystic ovary syndrome. Taiwan J Obstet Gynecol 51, 565-571 http://dx.doi.org/10.1016/j.tjog.2012.09.011
  • Wu, M. H., Lin, S. C., Hsiao, K. Y., and Tsai, S. J. (2011) Hypoxia-inhibited dual-specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression. J Pathol 225, 390-400 PMID:21984126
  • Wang, H. C., Chen, Y. H., Kao, H. Y., and Tsai, S. J. (2011) Inference of transcriptional regulatory network by bootstrapping patterns. Bioinformatics 27, 1422-1428 PMID:21450714
  • Teng, I. W., Hou, P. C., Lee, K. D., Chu, P. Y., Yeh, K. T., Jin, V. X., Tseng, M. J., Tsai, S. J., Chang, Y. S., Wu, C. S., Sun, H. S., Tsai, K. D., Jeng, L. B., Nephew, K. P., Huang, T. H., Hsiao, S. H., and Leu, Y. W. (2011) Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells. Cancer research 71, 4653-4663 PMID:21518779
  • Tang, Y. T., Li, S. J., Kao, H. Y., Tsai, S. J., and Wang, H. C. (2011) Using unsupervised patterns to extract gene regulation relationships for network construction. PLoS One 6, e19633 PMID:21573008
  • Lu, C. W., Lin, S. C., Chien, C. W., Lin, S. C., Lee, C. T., Lin, B. W., Lee, J. C., and Tsai, S. J. (2011) Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. Am J Pathol 179, 1405-1414 PMID:21763680
  • Lin, Y. S., Tsai, S. J., Lin, M. W., Yang, C. T., Huang, M. F., and Wu, M. H. (2011) Interleukin-6 as an early chronic inflammatory marker in polycystic ovary syndrome with insulin receptor substrate-2 polymorphism. American journal of reproductive immunology (New York, N.Y. : 1989) 66, 527-533 PMID:21801267
  • Lin, S. C., Chien, C. W., Lee, J. C., Yeh, Y. C., Hsu, K. F., Lai, Y. Y., Lin, S. C., and Tsai, S. J. (2011) Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. J Clin Invest 121, 1905-1916 PMID:21490398
  • Wu, M. H., Lu, C. W., Chuang, P. C., and Tsai, S. J. (2010) Prostaglandin E2: the master of endometriosis? Exp Biol Med (Maywood). 235(6), 668-77 PMID:20511671
  • Wu, M. H., Huang, M. F., Chang, F. M., and Tsai, S. J. (2010) Leptin on peritoneal macrophages of patients with endometriosis. American journal of reproductive immunology (New York, N.Y. : 1989) 63, 214-221 PMID:20047585
  • Lin, Y. M., Tsai, C. C., Chung, C. L., Chen, P. R., Sun, H. S., Tsai, S. J., and Huang, B. M. (2010) Fibroblast growth factor 9 stimulates steroidogenesis in postnatal Leydig cells. International journal of andrology 33, 545-553 PMID:19508331
  • Hsiao, S. H., Lee, K. D., Hsu, C. C., Tseng, M. J., Jin, V. X., Sun, W. S., Hung, Y. C., Yeh, K. T., Yan, P. S., Lai, Y. Y., Sun, H. S., Lu, Y. J., Chang, Y. S., Tsai, S. J., Huang, T. H., and Leu, Y. W. (2010) DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination. Biochemical and biophysical research communications 400, 305-312 PMID:20727853
  • Chuang, P. C., Lin, Y. J., Wu, M. H., Wing, L. Y., Shoji, Y., and Tsai, S. J. (2010) Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis. Am J Pathol 176, 850-860 PMID:20035060
  • Chen, W., Tsai, S. J., Sheu, H. M., Tsai, J. C., and Zouboulis, C. C. (2010) Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. Experimental dermatology 19, 470-472 PMID:20337700
  • Chen, T. M., Hsu, C. H., Tsai, S. J., and Sun, H. S. (2010) AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay. Nucleic Acids Res 38, 8061-8071 PMID:20716519
  • Pan, H. A., Lee, Y. C., Teng, Y. N., Tsai, S. J., Lin, Y. M., and Kuo, P. L. (2009) CDC25 protein expression and interaction with DAZL in human corpus luteum. Fertility and sterility 92, 1997-2003 PMID:19006796
  • Chuang, P. C., Wu, M. H., Shoji, Y., and Tsai, S. J. (2009) Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosis. J Pathol 219, 232-241 PMID:19606481
  • Chen, W., Tsai, S. J., Wang, C. A., Tsai, J. C., and Zouboulis, C. C. (2009) Human sebocytes express prostaglandin E2 receptors EP2 and EP4 but treatment with prostaglandin E2 does not affect testosterone production. The British journal of dermatology 161, 674-677 PMID:19438438
  • Yang, C. Y., Wang, Y. J., Chen, P. C., Tsai, S. J., and Guo, Y. L. (2008) Exposure to a mixture of polychlorinated biphenyls and polychlorinated dibenzofurans resulted in a prolonged time to pregnancy in women. Environmental health perspectives 116, 599-604 PMID:18470317
  • Lu, C. W., Lin, S. C., Chen, K. F., Lai, Y. Y., and Tsai, S. J. (2008) Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. The Journal of biological chemistry 283, 28106-28114 PMID:18718909
  • Hsu, C. C., Lu, C. W., Huang, B. M., Wu, M. H., and Tsai, S. J. (2008) Cyclic adenosine 3',5'-monophosphate response element-binding protein and CCAAT/enhancer-binding protein mediate prostaglandin E2-induced steroidogenic acute regulatory protein expression in endometriotic stromal cells. Am J Pathol 173, 433-441 PMID:18583320
  • Chien, C. W., Lin, S. C., Lai, Y. Y., Lin, B. W., Lin, S. C., Lee, J. C., and Tsai, S. J. (2008) Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 14, 8043-8051 PMID:19073968
  • Wu, M. H., Shoji, Y., Chuang, P. C., and Tsai, S. J. (2007) Endometriosis: disease pathophysiology and the role of prostaglandins. Expert reviews in molecular medicine 9, 1-20 PMID:17227592
  • Wu, M. H., Chen, K. F., Lin, S. C., Lgu, C. W., and Tsai, S. J. (2007) Aberrant expression of leptin in human endometriotic stromal cells is induced by elevated levels of hypoxia inducible factor-1alpha. Am J Pathol 170, 590-598 PMID:17255327
  • Chan, H. H., Tsai, S. T., and Sun, H. S. (2007) TAG: a comprehensive database for cancer research. Nucleic Acids Res Molecular Biology Database Collection, # 922
  • Chen, W., Yang, C. C., Tsai, R. Y., Liao, C. Y., Yen, Y. T., Hung, C. L., Chen, K. F., Tsai, S. J., and Zouboulis, C. C. (2007) Expression of sex-determining genes in the scalp of men with androgenetic alopecia. Dermatology (Basel, Switzerland) 214, 199-204 PMID:17377380
  • Chen, T. M., Kuo, P. L., Hsu, C. H., Tsai, S. J., Chen, M. J., Lin, C. W., and Sun, H. S. (2007) Microsatellite in the 3' untranslated region of human fibroblast growth factor 9 (FGF9) gene exhibits pleiotropic effect on modulating FGF9 protein expression. Human mutation 28, 98 PMID:17154280
  • Chuang, P. C., Sun, H. S., Chen, T. M., and Tsai, S. J. (2006) Prostaglandin E2 induces fibroblast growth factor 9 via EP3-dependent protein kinase Cdelta and Elk-1 signaling. Molecular and cellular biology 26, 8281-8292 PMID:16982695
  • Chen, Y. F., Kou, P. L., Tsai, S. J., Chen, K. F., Chan, H. H., Chen, C. M., and Sun, H. S. (2006) Computational analysis and refinement of sequence structure on chromosome 22q11.2 region: application to the development of quantitative real-time PCR assay for clinical diagnosis. Genomics 87, 290-297 PMID:16307865
  • Chen, W., Yang, C. C., Liao, C. Y., Hung, C. L., Tsai, S. J., Chen, K. F., Sheu, H. M., and Zouboulis, C. C. (2006) Expression of sex-determining genes in human sebaceous glands and their possible role in the pathogenesis of acne. Journal of the European Academy of Dermatology and Venereology : JEADV 20, 846-852 PMID:16898909
  • Chen, W., Tsai, S. J., Liao, C. Y., Tsai, R. Y., Chen, Y. J., Pan, B. J., Hung, C. L., and Zouboulis, C. C. (2006) Higher levels of steroidogenic acute regulatory protein and type I 3beta-hydroxysteroid dehydrogenase in the scalp of men with androgenetic alopecia. The Journal of investigative dermatology 126, 2332-2335 PMID:16778788
  • Wu, M. H., Wang, C. A., Lin, C. C., Chen, L. C., Chang, W. C., and Tsai, S. J. (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1beta in normal and endometriotic stromal cells. J Clin Endocrinol Metab 90, 286-295 PMID:15483103
  • Wu, M. H., Shoji, Y., Wu, M. C., Chuang, P. C., Lin, C. C., Huang, M. F., and Tsai, S. J. (2005) Suppression of matrix metalloproteinase-9 by prostaglandin E(2) in peritoneal macrophage is associated with severity of endometriosis. Am J Pathol 167, 1061-1069 PMID:16192641
  • Wing, L. Y., Chen, H. M., Chuang, P. C., Wu, M. H., and Tsai, S. J. (2005) The mammalian target of rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9-induced cell proliferation. The Journal of biological chemistry 280, 19937-19947 PMID:15760907
  • Tsai, S. J., Lin, S. J., Cheng, Y. M., Chen, H. M., and Wing, L. Y. (2005) Expression and functional analysis of pituitary tumor transforming gene-1 [corrected] in uterine leiomyomas. J Clin Endocrinol Metab 90, 3715-3723 PMID:15769981
  • Chen, W., Chen, G. Y., Tsai, S. J., Wang, P. W., Sheu, H. M., Shen, Y. S., and Chen, F. F. (2005) Mild cutaneous manifestation in two young women with extraordinary hyperandrogenemia. Dermatology (Basel, Switzerland) 210, 49-52 PMID:15604546
  • Chen, K. F., Lai, Y. Y., Sun, H. S., and Tsai, S. J. (2005) Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha. Nucleic Acids Res 33, 5190-5198 PMID:16155188
  • Wu, M. H., Huang, M. F., Tsai, S. J., Pan, H. A., Cheng, Y. C., and Lin, Y. S. (2004) Effects of laparoscopic ovarian drilling on young adult women with polycystic ovarian syndrome. The Journal of the American Association of Gynecologic Laparoscopists 11, 184-190 PMID:15200772
  • Huang, B. M., Hsiao, K. Y., Chuang, P. C., Wu, M. H., Pan, H. A., and Tsai, S. J. (2004) Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. Biology of reproduction 70, 1358-1364 PMID:14711788
  • Wu, M. H., Tsai, S. J., Pan, H. A., Hsiao, K. Y., and Chang, F. M. (2003) Three-dimensional power Doppler imaging of ovarian stromal blood flow in women with endometriosis undergoing in vitro fertilization. Ultrasound Obstet Gynecol 21, 480-485 PMID:12768561
  • Wing, L. Y., Chuang, P. C., Wu, M. H., Chen, H. M., and Tsai, S. J. (2003) Expression and mitogenic effect of fibroblast growth factor-9 in human endometriotic implant is regulated by aberrant production of estrogen. J Clin Endocrinol Metab 88, 5547-5554 PMID:14602803
  • Vasconcelos, J. L., Sangsritavong, S., Tsai, S. J., and Wiltbank, M. C. (2003) Acute reduction in serum progesterone concentrations after feed intake in dairy cows. Theriogenology 60, 795-807 PMID:12935858
  • Sun, H. S., Hsiao, K. Y., Hsu, C. C., Wu, M. H., and Tsai, S. J. (2003) Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor. Endocrinology 144, 3934-3942 PMID:12933667
  • Ip, S. P., Wong, T. P., Tsai, S. J., and Leung, P. S. (2003) The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic condition. Journal of molecular endocrinology 31, 563-571 PMID:14664716
  • Hsu, C. C., Tsai, S. J., Huang, Y. L., and Huang, B. M. (2003) Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. FEBS letters 543, 140-143 PMID:12753921
  • Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. (2003) In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 73, 2127-2136 PMID:12899935
  • Yang, A. L., Tsai, S. J., Jiang, M. J., Jen, C. J., and Chen, H. I. (2002) Chronic exercise increases both inducible and endothelial nitric oxide synthase gene expression in endothelial cells of rat aorta. Journal of biomedical science 9, 149-155 PMID:11914582
  • Wu, M. H., Sun, H. S., Lin, C. C., Hsiao, K. Y., Chuang, P. C., Pan, H. A., and Tsai, S. J. (2002) Distinct mechanisms regulate cyclooxygenase-1 and-2 in peritoneal macrophages of women with and without endometriosis. Molecular Human Reproduction 8, 1103-1110 PMID:12468643
  • Wu, M. H., Chuang, P. C., Chen, H. M., Lin, C. C., and Tsai, S. J. (2002) Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation. Mol Hum Reprod 8, 456-464 PMID:11994543
  • Tsai, S. J., Wu, M. H., Chen, H. M., Chuang, P. C., and Wing, L. Y. (2002) Fibroblast growth factor-9 is an endometrial stromal growth factor. Endocrinology 143, 2715-2721 PMID:12072406
  • Pan, H. A., Tsai, S. J., Chen, C. W., Lee, Y. C., Lin, Y. M., and Kuo, P. L. (2002) Expression of DAZL protein in the human corpus luteum. Mol Hum Reprod 8, 540-545 PMID:12029071
  • Lin, Y. M., Chen, C. W., Sun, H. S., Tsai, S. J., Lin, J. S., and Kuo, P. L. (2002) Presence of DAZL transcript and protein in mature human spermatozoa. Fertility and sterility 77, 626-629 PMID:11872225
  • Diaz, F. J., Anderson, L. E., Wu, Y. L., Rabot, A., Tsai, S. J., and Wiltbank, M. C. (2002) Regulation of progesterone and prostaglandin F2alpha production in the CL. Molecular and cellular endocrinology 191, 65-80 PMID:12044920
  • Tsai, S. J., Wu, M. H., Lin, C. C., Sun, H. S., and Chen, H. M. (2001) Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab 86, 5765-5773 PMID:11739437
  • Tsai, S. J., Wu, M. H., Chuang, P. C., and Chen, H. M. (2001) Distinct regulation of gene expression by prostaglandin F(2alpha) (PGF(2alpha)) is associated with PGF(2alpha) resistance or susceptibility in human granulosa-luteal cells. Mol Hum Reprod 7, 415-423 PMID:11331663
  • Tsai, S. J., and Wiltbank, M. C. (2001) Differential effects of prostaglandin F2alpha on in vitro luteinized bovine granulosa cells. Reproduction (Cambridge, England) 122, 245-253 PMID:11467975
  • Tsai, S. J., Kot, K., Ginther, O. J., and Wiltbank, M. C. (2001) Temporal gene expression in bovine corpora lutea after treatment with PGF2alpha based on serial biopsies in vivo. Reproduction (Cambridge, England) 121, 905-913 PMID:11373177
  • Lin, Y. M., Chen, C. W., Sun, H. S., Tsai, S. J., Hsu, C. C., Teng, Y. N., Lin, J. S., and Kuo, P. L. (2001) Expression patterns and transcript concentrations of the autosomal DAZL gene in testes of azoospermic men. Mol Hum Reprod 7, 1015-1022 PMID:11675467
  • Leung, P. S., Tsai, S. J., Wallukat, G., Leung, T. N., and Lau, T. K. (2001) The upregulation of angiotensin II receptor AT(1) in human preeclamptic placenta. Molecular and cellular endocrinology 184, 95-102 PMID:11694345
  • Huang, B. M., Hsu, C. C., Tsai, S. J., Sheu, C. C., and Leu, S. F. (2001) Effects of Cordyceps sinensis on testosterone production in normal mouse Leydig cells. Life Sci 69, 2593-2602 PMID:11712663
  • Anderson, L. E., Wu, Y. L., Tsai, S. J., and Wiltbank, M. C. (2001) Prostaglandin F(2alpha) receptor in the corpus luteum: recent information on the gene, messenger ribonucleic acid, and protein. Biology of reproduction 64, 1041-1047 PMID:11259248
  • Kot, K., Anderson, L. E., Tsai, S. J., Wiltbank, M. C., and Ginther, O. J. (1999) Transvaginal, ultrasound-guided biopsy of the corpus luteum in cattle. Theriogenology 52, 987-993 PMID:10735106
  • Tsai, S. J., and Wiltbank, M. C. (1998) Prostaglandin F2alpha regulates distinct physiological changes in early and mid-cycle bovine corpora lutea. Biology of reproduction 58, 346-352 PMID:9475388
  • Tsai, S. J., Anderson, L. E., Juengel, J., Niswender, G. D., and Wiltbank, M. C. (1998) Regulation of prostaglandin F2 alpha and E receptor mRNA by prostaglandin F 2 alpha in ovine corpora lutea. Journal of reproduction and fertility 114, 69-75 PMID:9875157
  • Tsai, S. J., and Wiltbank, M. C. (1997) Prostaglandin F2alpha induces expression of prostaglandin G/H synthase-2 in the ovine corpus luteum: a potential positive feedback loop during luteolysis. Biology of reproduction 57, 1016-1022 PMID:9369165
  • Tsai, S. J., Juengel, J. L., and Wiltbank, M. C. (1997) Hormonal regulation of monocyte chemoattractant protein-1 messenger ribonucleic acid expression in corpora lutea. Endocrinology 138, 4517-4520 PMID:9322976
  • Burns, P. D., Tsai, S. J., Wiltbank, M. C., Hayes, S. H., Graf, G. A., and Silvia, W. J. (1997) Effect of oxytocin on concentrations of prostaglandin H synthase-2 mRNA in ovine endometrial tissue in vivo. Endocrinology 138, 5637-5640 PMID:9389552
  • Tsai, S. J., Wiltbank, M. C., and Bodensteiner, K. J. (1996) Distinct mechanisms regulate induction of messenger ribonucleic acid for prostaglandin (PG) G/H synthase-2, PGE (EP3) receptor, and PGF2 alpha receptor in bovine preovulatory follicles. Endocrinology 137, 3348-3355 PMID:8754761
  • Tsai, S. J., and Wiltbank, M. C. (1996) Quantification of mRNA using competitive RT-PCR with standard-curve methodology. Biotechniques 21, 862-866 PMID:8922627
  • Duello, T. M., Tsai, S. J., and Van Ess, P. J. (1993) In situ demonstration and characterization of progonadotropin-releasing hormone messenger ribonucleic acid in first trimester human placentas. Endocrinology 133, 2617-2623 PMID:8243285
  • Yuan, C. C., Tsai, L. C., Hsu, S. C., Ng, H. T., Tsai, S. J., Chen, H. M., Hung, M. W., Ho, C. K., Ho, D. M., and Gill, T. J., 3rd. (1992) Production and characterisation of a monoclonal antibody (Cx-99) against cervical carcinoma. Br J Cancer 65, 201-207 PMID:1739618
  • Tsai, L. C., Tang, R. B., Hung, M. W., Chen, H. M., and Tsai, S. J. (1990) Expression of serum IL-2, IL-2R, and CD8 levels during hyposensitization in house-dust-sensitive asthmatics. J Asthma 27, 307-313 PMID:2122966
  • Tsai, L.C., Hung, M. W., Chen, H.M., Chang, Z.N., and Tsai, S.J. (1989) Measurement of specific IgE antibody in mite-sensitive asthmatic children by enzyme-linked immunosorbent assay. Chin Med J (Taipei) 44, 352-357
  • Yuan, C. C., Tsai, L. T., Tsai, S. J., Hsu, S. C., Ho, D. M., Chen, H. M., Hung, M. W., Lee, L. C., and Ng, H. T. (1989) Immunohistochemical study of carcinoembryonic antigen in cervical cancer-using a monoclonal antibody Mab C27. Chin Med J (Taipei) 44, 341-346

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