NCKU, 生理學科暨研究所

NCKU, 生理學科暨研究所

蔡少正 特聘教授

蔡少正(Shaw-Jenq Tsai特聘教授

學經歷:

成功大學 學士,1982-1986

美國東密西根大學 碩士,1990-1992

美國威斯康辛大學 博士,1993-1997

美國威斯康辛大學 博士後研究,1997-1998

成大生理所 助理教授,1998-2002

成功大學生物資訊中心 負責人,2001-迄今

成大生理所 副教授,2002-2005

成大生理所 教授,2005-迄今

成大生理所 教授兼所長,2006-2009

成大生理所 特聘教授,2008-迄今
美國休士頓貝勒醫學院 訪問教授,2010-2011

科技部生命科學司 司長,2014-2017

第二十四屆中國生理學會 理事長,2016-迄今

專長學科

轉譯醫學、生物資訊、細胞生物學、表觀遺傳學、子宮內膜異位症

獎勵事項

國科會傑出研究獎(2011
美國實驗生物醫學協會年傑出科學家獎(2014)

E-mail

seantsai@mail.ncku.edu.tw

辦公室

   82-0701 分機:5426

實驗室

82-0734 分機:5429

嗜好:任何活的東西

研究方向及興趣:

本實驗室主要有三個研究方向:
一、缺氧誘導因子(HIF-1α)調控基因與癌症抗藥性之研究。細胞因為缺氧會產生種種不同的生理反應或病理變化,包括學習記憶、癌症、心血管疾病、生長遲緩、腦部疾病、肺部疾病等。我們利用生物資訊學的方法,將基因體中會受缺氧誘導因子調控之基因(包括人類、大鼠、小鼠)找尋出來,並研究其在生理、病理上的功能,尤其著重在癌症抗藥性方面的探討,目前以大腸癌及胰臟癌的抗藥性機制為重點
二、研究整個基因體的調控(Gene regulatory network)及細胞分化、去分化及再分化的機轉。表觀基因體調控(epigenomic modification and reprograming)對細胞之命運影響至巨,甚或造成細胞病變。我們利用生物資訊學、功能性基因體學、系統生物學等尖端方法,對此一現象作深入的研究
三、探討子宮內膜異位 (endometriosis)成因之分子機制,子宮內膜異位症約佔生殖年齡期婦女人數的10-15%,大部分會導致不孕症的發生,目前有關子宮內膜異位形成之原因,並不清楚。本實驗室過去十幾年的研究,在這個領域已有相當傑出的成果,居於世界領先地位,未來將著重在整合性基因功能上的研究,期盼能發展出可以治療這個疾病的方法或藥物。

實驗室成員:

現在成員

助理:黃美鳳(2001)、賴嬿羽(2003)、葉憶萱(2008)、湯宜禎(2013)、洪淑貞(2014)

博士後研究:蕭貴陽(2012)王竹安(2014)、許佩玲(2017)

博士班:李祐華(2011)李脩琦(2012)李婉寧(2016)

碩士班:葛宇庭(2016)、戴昱菁(2016)

大學部:張凱禮(2016)、蘇虹綺(2017)

過去成員

助理:葉惠群、廖晨喻、王致權(2009)、曹碧華(2010)

博士後研究:莊佩錦()、庄司豊(2004)、呂淳雯()、林世杰(2011)、廖婉玲(2013)

博士班:吳孟興(89)、莊佩錦(91)、林世杰(96)、呂淳雯(93)、簡郡緯(98)、林劭潔、李祐華(100)、侯沛琪(99)

碩士班:莊佩錦(87)、林晨鐘(88)、蕭貴陽(89)、許智超(90)、陳克帆(91)、林世杰(91)、王竹安(91)、蔡秀真(92)、呂淳雯(92)、吳軍緯(93)、郭瓊茵(93)、簡郡緯(94)、古士宜(94)、李脩琦(98)、張于凡(98)、李祐華(99)、黃詩雅(99)、林怡岑(99)、蔡佳玲(100)、張寧(101)、傅兆麟(102)、張以恆(103)、徐敬庭(103)、陳思瑜(103)、陳一誠(104)

大學部:林晨鐘(1998)、蕭貴陽(1999)、陳秀梅(P)(1999)、林世杰(2000)、陳克帆(2000)、吳孟輯(2002)、陳宥芳(2002)、蔡宗翰(2003)、黃智群(2006)、張雅嵐(2006)、李祐華(2006)

相關著作(自2010..

  • Lin, S. C., Lee, H. C., Hou, P. C., Fu, J. L., Wu, M. H., and Tsai, S. J. (2017) Targeting hypoxia-mediated YAP1 nuclear translocation ameliorates pathogenesis of endometriosis without compromising maternal fertility. Journal of Pathology 242, 476-487 PMID:28652251
  • Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S., and Tsai, S. J. (2017) Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness. Cancer research 77, 4305-4316 PMID:28608501
  • Hsiao, K. Y., Lin, Y. C., Gupta, S. K., Chang, N., Yen, L., Sun, H. S., and Tsai, S. J. (2017) Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. Cancer research 77, 2339-2350 PMID:28249903
  • Lin, S. C., Hsiao, K. Y., Chang, N., Hou, P. C., and Tsai, S. J. (2017) Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer. J Pathol 241, 638-648 PMID: 28026024
  • Lin, S. C., Kao, C. Y., Lee, H. J., Creighton, C. J., Ittmann, M. M., Tsai, S. J., Tsai, S. Y., and Tsai, M. J. (2016) Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun 7, 11418 PMID:27108958
  • Lai, M. S., Wang, C. Y., Yang, S. H., Wu, C. C., Sun, H. S., Tsai, S. J., Chuang, J. I., Chen, Y. C., and Huang, B. M. (2016) The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes. Organogenesis 12, 61-77 PMID:27078042
  • Chien, C. W., Hou, P. C., Wu, H. C., Chang, Y. L., Lin, S. C., Lin, S. C., Lin, B. W., Lee, J. C., Chang, Y. J., Sun, H. S., and Tsai, S. J. (2016) Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. Oncogene PMID:27132510
  • Wang, C. A., and Tsai, S. J. (2015) The non-canonical role of vascular endothelial growth factor-C axis in cancer progression. Exp Biol Med (Maywood) 240, 718-724 PMID:25888649
  • Liang, K. C., Tseng, J. T., Tsai, S. J., and Sun, H. S. (2015) Characterization and distribution of repetitive elements in association with genes in the human genome. Comput Biol Chem 57, 29-38 PMID:25748288
  • Hsiao, K. Y., Wu, M. H., Chang, N., Yang, S. H., Wu, C. W., Sun, H. S., and Tsai, S. J. (2015) Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis. Mol Hum Reprod 21, 894-904 PMID:26433194
  • Hsiao, K. Y., Lin, S. C., Wu, M. H., and Tsai, S. J. (2015) Pathological functions of hypoxia in endometriosis. Front Biosci (Elite Ed) 7, 309-321 PMID:25553382
  • Fu, M. H., Li, C. L., Lin, H. L., Tsai, S. J., Lai, Y. Y., Chang, Y. F., Cheng, P. H., Chen, C. M., and Yang, S. H. (2015) The Potential Regulatory Mechanisms of miR-196a in Huntington's Disease through Bioinformatic Analyses. PLoS One 10, e0137637 PMID:26376480
  • Chuang, J. I., Huang, J. Y., Tsai, S. J., Sun, H. S., Yang, S. H., Chuang, P. C., Huang, B. M., and Ching, C. H. (2015) FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free Radic Biol Med 89, 274-286 PMID:26424114
  • Tang, Y. T., Kao, H. Y., Tsai, S. J., and Wang, H. C. (2014) A semi-supervised, weighted pattern-learning approach for extraction of gene regulation relationships from scientific literature. Int J Data Min Bioinform 9, 401-416 PMID:25757247
  • Lin, S. C., Liao, W. L., Lee, J. C., and Tsai, S. J. (2014) Hypoxia-regulated gene network in drug resistance and cancer progression. Exp Biol Med (Maywood) 239, 779-792 PMID:24812122
  • Lin, S. C., Li, Y. H., Wu, M. H., Chang, Y. F., Lee, D. K., Tsai, S. Y., Tsai, M. J., and Tsai, S. J. (2014) Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. J Clin Endocrinol Metab 99, E427-437 PMID:24423359
  • Liao, W.-L., Lin, S.-C., Sunny Sun, H., and Tsai, S. J. (2014) Hypoxia-induced tumor malignancy and drug resistance: Role of microRNAs. Biomarkers and Genomic Medicine 6, 1-11 http://dx.doi.org/10.1016/j.bgm.2014.01.003
  • Lai, M. S., Cheng, Y. S., Chen, P. R., Tsai, S. J., and Huang, B. M. (2014) Fibroblast growth factor 9 activates akt and MAPK pathways to stimulate steroidogenesis in mouse leydig cells. PLoS One 9, e90243 PMID:24603862
  • Chen, T. M., Shih, Y. H., Tseng, J. T., Lai, M. C., Wu, C. H., Li, Y. H., Tsai, S. J., and Sun, H. S. (2014) Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation. Nucleic Acids Res 42, 2932-2944 PMID:24334956
  • Wu, S. P., Cheng, C. M., Lanz, R. B., Wang, T., Respress, J. L., Ather, S., Chen, W., Tsai, S. J., Wehrens, X. H., Tsai, M. J., and Tsai, S. Y. (2013) Atrial identity is determined by a COUP-TFII regulatory network. Developmental cell 25, 417-426 http://dx.doi.org/10.1016/j.devcel.2013.04.017
  • Wu, M. H., Chuang, P. C., Lin, Y. J., and Tsai, S. J. (2013) Suppression of annexin A2 by prostaglandin E(2) impairs phagocytic ability of peritoneal macrophages in women with endometriosis. Hum Reprod 28, 1045-1053 PMID:23340055
  • Wang, H. C., Kooi, T. K., Kao, H. Y., Lin, S. C., and Tsai, S. J. (2013) Using positive and negative patterns to extract information from journal articles regarding the regulation of a target gene by a transcription factor. Comput Biol Med 43, 2214-2221 PMID:24290938
  • Qin, J., Wu, S. P., Creighton, C. J., Dai, F., Xie, X., Cheng, C. M., Frolov, A., Ayala, G., Lin, X., Feng, X. H., Ittmann, M. M., Tsai, S. J., Tsai, M. J., and Tsai, S. Y. (2013) COUP-TFII inhibits TGF-beta-induced growth barrier to promote prostate tumorigenesis. Nature 493, 236-240 PMID:23201680
  • Lai, M. C., Wang, S. W., Cheng, L., Tarn, W. Y., Tsai, S. J., and Sun, H. S. (2013) Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation. PLoS One 8, e68665 PMID:23840900
  • Cheng, P. H., Li, C. L., Chang, Y. F., Tsai, S. J., Lai, Y. Y., Chan, A. W., Chen, C. M., and Yang, S. H. (2013) miR-196a ameliorates phenotypes of Huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models. Am J Hum Genet 93, 306-312 PMID:23810380
  • Chen, J. S., Hung, W. S., Chan, H. H., Tsai, S. J., and Sun, H. S. (2013) In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics 29, 420-427 PMID:23267173
  • Chen, H. M., Lin, Y. H., Cheng, Y. M., Wing, L. Y., and Tsai, S. J. (2013) Overexpression of integrin-beta1 in leiomyoma promotes cell spreading and proliferation. J Clin Endocrinol Metab 98, E837-846 PMID:23482612
  • Wu, M. H., Lu, C. W., Chang, F. M., and Tsai, S. J. (2012) Estrogen receptor expression affected by hypoxia inducible factor-1alpha in stromal cells from patients with endometriosis. Taiwan J Obstet Gynecol 51, 50-54 http://dx.doi.org/10.1016/j.tjog.2012.01.010
  • Wiltbank, M. C., Salih, S. M., Atli, M. O., Luo, W., Bormann, C. L., Ottobre, J. S., Vezina, C. M., Mehta, V., Diaz, F. J., Tsai, S. J., and Sartori, R. (2012) Comparison of endocrine and cellular mechanisms regulating the corpus luteum of primates and ruminants. Animal reproduction / Colegio Brasileiro de Reproducao Animal 9, 242-259
  • Wang, C. C., Lin, S. C., Lee, Y. H., and Tsai, S.J. (2012) Hypoxia-Induced Tumor Progression and Drug Resistance: From Current Understandings to Future Perspectives. Adaptive Medicine 4, 132-144 DOI:10.4247/AM.2012.ABC033
  • Lin, S. C., Wang, C. C., Wu, M. H., Yang, S. H., Li, Y. H., and Tsai, S. J. (2012) Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. J Clin Endocrinol Metab 97, E1515-1523 PMID:22648654
  • Lin, M. W., Tsai, S. J., Chou, P. Y., Huang, M. F., Sun, H. S., and Wu, M. H. (2012) Vitamin D receptor 1a promotor -1521 G/C and -1012 A/G polymorphisms in polycystic ovary syndrome. Taiwan J Obstet Gynecol 51, 565-571 http://dx.doi.org/10.1016/j.tjog.2012.09.011
  • Wu, M. H., Lin, S. C., Hsiao, K. Y., and Tsai, S. J. (2011) Hypoxia-inhibited dual-specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression. J Pathol 225, 390-400 PMID:21984126
  • Wang, H. C., Chen, Y. H., Kao, H. Y., and Tsai, S. J. (2011) Inference of transcriptional regulatory network by bootstrapping patterns. Bioinformatics 27, 1422-1428 PMID:21450714
  • Teng, I. W., Hou, P. C., Lee, K. D., Chu, P. Y., Yeh, K. T., Jin, V. X., Tseng, M. J., Tsai, S. J., Chang, Y. S., Wu, C. S., Sun, H. S., Tsai, K. D., Jeng, L. B., Nephew, K. P., Huang, T. H., Hsiao, S. H., and Leu, Y. W. (2011) Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells. Cancer research 71, 4653-4663 PMID:21518779
  • Tang, Y. T., Li, S. J., Kao, H. Y., Tsai, S. J., and Wang, H. C. (2011) Using unsupervised patterns to extract gene regulation relationships for network construction. PLoS One 6, e19633 PMID:21573008
  • Lu, C. W., Lin, S. C., Chien, C. W., Lin, S. C., Lee, C. T., Lin, B. W., Lee, J. C., and Tsai, S. J. (2011) Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. Am J Pathol 179, 1405-1414 PMID:21763680
  • Lin, Y. S., Tsai, S. J., Lin, M. W., Yang, C. T., Huang, M. F., and Wu, M. H. (2011) Interleukin-6 as an early chronic inflammatory marker in polycystic ovary syndrome with insulin receptor substrate-2 polymorphism. American journal of reproductive immunology (New York, N.Y. : 1989) 66, 527-533 PMID:21801267
  • Lin, S. C., Chien, C. W., Lee, J. C., Yeh, Y. C., Hsu, K. F., Lai, Y. Y., Lin, S. C., and Tsai, S. J. (2011) Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. J Clin Invest 121, 1905-1916 PMID:21490398
  • Wu, M. H., Lu, C. W., Chuang, P. C., and Tsai, S. J. (2010) Prostaglandin E2: the master of endometriosis? Exp Biol Med (Maywood). 235(6), 668-77 PMID:20511671
  • Wu, M. H., Huang, M. F., Chang, F. M., and Tsai, S. J. (2010) Leptin on peritoneal macrophages of patients with endometriosis. American journal of reproductive immunology (New York, N.Y. : 1989) 63, 214-221 PMID:20047585
  • Lin, Y. M., Tsai, C. C., Chung, C. L., Chen, P. R., Sun, H. S., Tsai, S. J., and Huang, B. M. (2010) Fibroblast growth factor 9 stimulates steroidogenesis in postnatal Leydig cells. International journal of andrology 33, 545-553 PMID:19508331
  • Hsiao, S. H., Lee, K. D., Hsu, C. C., Tseng, M. J., Jin, V. X., Sun, W. S., Hung, Y. C., Yeh, K. T., Yan, P. S., Lai, Y. Y., Sun, H. S., Lu, Y. J., Chang, Y. S., Tsai, S. J., Huang, T. H., and Leu, Y. W. (2010) DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination. Biochemical and biophysical research communications 400, 305-312 PMID:20727853
  • Chuang, P. C., Lin, Y. J., Wu, M. H., Wing, L. Y., Shoji, Y., and Tsai, S. J. (2010) Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis. Am J Pathol 176, 850-860 PMID:20035060
  • Chen, W., Tsai, S. J., Sheu, H. M., Tsai, J. C., and Zouboulis, C. C. (2010) Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. Experimental dermatology 19, 470-472 PMID:20337700
  • Chen, T. M., Hsu, C. H., Tsai, S. J., and Sun, H. S. (2010) AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay. Nucleic Acids Res 38, 8061-8071 PMID:20716519

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