NCKU, 生理學科暨研究所

NCKU, 生理學科暨研究所

湯銘哲 特聘教授

湯銘哲Ming-Jer Tang)特聘教授

學經歷:

 

台北醫學大學 醫學士,1973-1980

美國密西根大學 生理學博士,1983-1987

成大醫學院生理所 副教授,教授,1990-2002

成大醫學院生理所 特聘教授2002-迄今

成功大學 教務長 2007-2011

東海大學 校長 2013-2016

 

專長學科

細胞生理學, 腎臟生理學, 細胞生物力學, 幹細胞及再生醫學

 

獎勵事項

國科會傑出研究獎(2003-2006),傑出研究計劃獎(2008-2011

成功大學特聘教授連續三次共九年(2002-2011

王民寧醫藥傑出貢獻獎 (2005)

台北醫學大學傑出校友學術成就獎(2007

國家衛生研究院”整合性醫藥衛生科技研究計畫”獲得經費補助達三次以上獎座(2004)

E-mail

mjtang1@mail.ncku.edu.tw

辦公室

82-0702 分機:5425

實驗室

82-0735 分機:5428

嗜好:藝術,音樂,文學,網球

研究方向及興趣:

We employed molecular, cellular and mechanobiological approach to study pathophysiological mechanisms of cancer, organ fibrosis and keloid. Particular questions are:

1. Most cancer tissues are rigid, but cancer cells are soft, why?

2. How does tissue stiffening affect the progression of organ fibrosis and whether stem cells are remedies for organ fibrosis?

3. How is mechanical force involved in pathogenesis of keloid?

實驗室成員:

現在成員

助理研究員:林錫慧博士

助理教授:許釗凱醫師

博士後研究學者:林秀冠博士,邱昱瑋博士

博士班:蔡靜宜(博五)

碩士班:韓佳霖(碩一)

助理:王曼薇

相關著作(PubMed連結)

1.  Huang YW, Chang SJ, Harn HI, Huang HT, Lin HH, Shen MR, Tang MJ, Chiu WT. Mechanosensitive Store-Operated Calcium Entry Regulates the Formation of Cell Polarity. J. Cell Physiol. 230: 2086-2097, 2015.

2.  Yu HW, Chen YQ, Huang CM, Liu CY, Chiou A, Wang YK, Tang MJ, Kuo JC.  β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration. J Cell Mol. Med. 19: 934-947, 2015.

3.  Harn HI, Wang YK, Hsu CK, Ho YT, Huang YW, Chiu WT, Lin HH, Cheng CM, Tang MJ. Mechanical coupling of cytoskeletal elasticity and force generation is crucial for understanding the migrating nature of keloid fibroblasts. Exp. Dermatol. 24: 579-584, 2015

4.  Liu CY, Lin HH, Tang MJ and Wang YK. Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation. Oncotarget 6: 15966-15983, 2015. (Co-corresponding author)

5.  Lin HH, Lin HK, Lin IH, Chiu YW, Chen HW, Liu CY, Harn HI, Chiu WT, Wang YK, Shen MR, and Tang MJ. Mechanical phenotypes of cancer cells: cell softening and the loss of stiffness sensing. Oncotarget 6: 20946-20958, 2015.

6.  Chen WC, Lin HH and Tang MJ. Matrix stiffness-regulated inverse expression of Krüppel-like factor 5 and Krüppel-like factor 4 in the pathogenesis of renal fibrosis. Am. J Pathol. 185: 2468-2481, 2015.

7.  Yeh YC and Tang MJ. Functions of DDR1 in epithelial cell differentiation. Chapter in: Discoidin Domain Receptors in Health and Diseases. Editors: R. Fridman and P. Huang. Springer Publisher, 2015.

8. Harn HI, Hsu CK, Wang YK, Huang YW, Chiu WT, Lin HH, Cheng CM, Tang MJ. Spatial distribution of filament elasticity determines the migratory behaviors of a cell. Cell Adhesion and Migration, Accepted 2016.

實驗室特色連結

實驗室活動照片連結