NCKU, 生理學科暨研究所

NCKU, 生理學科暨研究所

吳勝男 教授

吳勝男 教授

 

學經歷:

高雄醫學院 學士,1975-1982

台北榮民總醫院 住院醫師,1982-1985

維吉尼亞大學 碩士,1986-1988

佛羅里達大學 博士,1988-1989

佛羅里達大學 博士後,1989-1990

高雄醫學院 副教授,1990-1995

日本東京大學 訪問副教授 1993

高雄榮民總醫院 研究員1995-2003

美國維吉尼亞聯邦大學醫學中心 訪問教授,2010

成大生理所 教授,2003-迄今

專長學科

離子通道學、電生理學、藥理學、心臟血管生理學、神經內分泌學

獎勵事項

E-mail

snwu@mail.ncku.edu.tw

辦公室

82-0518 分機:5334

實驗室

82-0557分機:5751

嗜好:

研究方向及興趣:

1.     鈣離子活化鉀離子通道的活性對心臟功能影響之深入探討

2.     興奮性細胞中電壓性鈉離子電流,鈣離子活化鉀離子電流,與鈣離子活化氯離子電流的相互反應:實驗與理論性的研究

實驗室成員:

現在成員

碩士班:陳慧真(碩二)、張自東(碩一)、楊佳容(碩一)

 

過去成員

碩士班:黃彥銘(2015)、廖俞凱(2015)、林雅琪(2014)、許銘淳(2013)、黃獻慶(2012)、葉家禎(2012)、吳泳翰(2009)、彭翾(2009)、蔡家祚(2008)、林安安(2008)、吳智陽(2005)

博士班:王雅貞(2008)

相關著作(PubMed連結)

1.     Huang CW, Hung TY, Wu SN (2015, Nov).  The inhibitory actions by lacosamide, a functionalized amino acid, on voltage-gated Na+ currents. Neuroscience, 287, 125-136. (SCI). NSC 101-2320-B-006-009.

2.     Huang MH, Huang YM, Wu SN (2015, Nov).  The inhibition by oxaliplatin, a platinum-based anti-neoplastic agent, of the activity of intermediate-conductance Ca2+-activated K+ channels in human glioma cells.. Cell Physiol Biochem.

3.     Lo YC, Tseng YT, Liu CM, Wu BN, Wu SN (2015, Nov).

Actions of KMUP-1, a xanthing and pipearzine derivative, on voltage-gated Na+ and Ca2+-activated K+ currents in GH3 pituitary tumour cells. Br J Pharmacol, 172(21):51105122.

4.     Wu SN, Huang YM, Kao CA, Chen BS, Lo YC (2015, Nov). Investigations on contribution of glial inwardly-rectifying K+ current to membrane potential and ion flux: an experimental and theoretical study. Kaohsiung J Med Sci, 31(1), 917.

5.     Lee DS, Chen JH, Lundy DJ, Liu CH, Hwang SM, Pabon L, Shieh RC, Chen CC, Wu SN, Yan YT, Lee ST, Chiang PM, Chien S, Murry CE, Hsieh PC (2015, Sep).  Defined microRNAs induce aspects of maturation in mouse and human embryonic-stem-cell-derived cardiomyocytes. Cell Rep, 12(12):1960-1967. Cover article.

6.     So EC, Huang YM, Hsing CH, Liao YK, Wu SN (2015, Apr). Arecoline inhibits intermediate-conductance calcium-activated potassium channels in human glioblastoma cell lines. Eur J Pharmacol, 758, 177-187

7.     Wu SN, Huang YM, Liao YK (2015, Feb).  Effects of ibandronate sodium, a nitrogen-containing bisphosphonate, on intermediate-conductance calciumactivated potassium channels in osteoclast precursor cells (RAW 264.7). J Membr Biol, 248(1), 103-115. NSC 101-2320-B-006-009.

8.     Hsu HT, Tseng YT, Lo YC, Wu SN (2014, Dec).  Ability of naringenin, a bioflavonoid, to activate M-type potassium current in motor neuron-like cells and to increase BKCa-channel activity in HEK293T cells transfected with α-hSlo subunit. BMC Neurosci, 15, 135. NSC 98-2320-B-006-MY3.

9.     Chiang NJ, Wu SN, Kao CA, Huang YM, Chen LT (2014, Oct). Stimulation of electroporation-induced inward currents in glioblastoma cell lines by the heat shock protein inhibitor AUY922. Clin Exp Pharmacol Physiol, 41(10), 830-837.

10.  So EC, Lo YC, Chen LT, Kao CA, Wu SN (2014, Sep).  High effectiveness of triptolide, an active diterpenoid triepoxide, in suppressing Kir-channel currents from human glioma cells. Eur J Pharmcol, 738, 332-341. NSC 101-2320-B-006009. 

11.  So EC, Wu KC, Kao FC, Wu SN (2014, Feb).  Effects of midazolam on ion currents and membrane potential in differentiated motor neuron-like NSC-34 and NG108-15 cells. Eur J Pharmacol, 724, 152-160. NSC 100-2320-B-242-001.

12.  So EC, Tsai KL, Wu FT, Hsu MC, Wu KC, Wu SN (2013, Sep). Identification of minuscule inward currents as precursors to membrane electroporation-induced currents: real-time prediction of pore appearance. Cell Physiol Biochem, 32(2), 402-416. NSC 101-2320-B-006-009.

13.  Tsai KL, Chang HF, Wu SN (2013, Jul).  The inhibition of inwardly rectifying K+ channels by memantine in macrophages and microglial cells. Cell Physiol Biochem, 31(6), 938-951. NSC 101-2320-B-006-009.

14.  Huang CW, Hung TY, Liao YK, Hsu MC, Wu SN (2013, Jun). Underlying mechanism of regulatory actions of diclofenac, a nonsteroidal anti-inflammatory agent, on neuronal potassium channels and firing: an experimental and theoretical study. J Physiol Pharmacol, 64(3), 269-280. NSC 101-2320-B-006009.

15.  Huang CW, Lai MC, Cheng JT, Tsai JJ, Huang CC, Wu SN (2013, Jun). Pregabalin attenuates excitotoxicity in diabetes. PLoS One, 8(6), e65154.

16.  Huang MH, Lin KH, Chen SJ, Shen AY, Wu FT, Wu SN (2012, Oct).  Effects of ketamine and its metabolites on ion currents in differentiated hippocampal H19-7 neuronal cells and in HEK293T cells transfected with α-hslo subunit. Neurotoxicology, 33(5), 1058-1066. (SCI, TOXICOLOGY). NSC 101-2320-B006-009.

17.  Wu SN, Lo YC, Chen BS, Wu FT, So EC (2012, Oct).  Possible effects of reduced conductance in delayed-rectifier K+ current on neuronal firing. Mov Disord, 27(12), 1581-1582. (SCI, CLINICAL NEUROLOGY ). NSC 98-2320B-006-027-MY3.

18.  Wu SN, Yeh CC, Huang HC, So EC, Lo YC (2012, Oct). Electrophysiological characterization of sodium-activated potassium channels in NG108-15 and NSC34 motor neuron-like cells. Acta Physiol, 206(2), 120-134. (SCI, PHYSIOLOGY). NSC 98-2320-B-006-027-MY3.

19.  Hsu YY, Chen CS, Wu SN, Jong YJ, Lo YC (2012, Aug). Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC-34 motor neuron-like cells. Eur J Pharmacol Sci, 46, 415-25.

20.  Wu SN, Lo YC, Chen BS, So EC, Chen LT (2012, Aug). Contribution of blocked potassium current conductance and increased conductance of persistent sodium current to the afterdischarge in myelinated neuron. Muscle Nerve, 46(2), 297299.

21.  Huang CW, Chow JC, Tsai JJ, Wu SN (2012, Jun). Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability. Psychopharmacology, 221(4), 575-587. (SCI, PHARMACOLOGY & PHARMACY). NSC 98-2320-B027-MY3.

22.  So EC, Hsing CH, Liang CH, Wu SN (2012, May). The actions of mdivi-1, an inhibitor of mitochondrial fission, on rapidly activating delayed-rectifier K+ current and membrane potential in HL-1 murine atrial cardiomyocytes. Eur J Pharmacol, 683(1-3), 1-9. (SCI, PHARMACOLOGY & PHARMACY). NSC 98-2320-B-006-027-MY3.

23.  Wu SN, Yang WH, Yeh CC, Huang HC (2012, May). The inhibition by di(2ethylhexyl)-phthalate of erg-mediated K+ current in pituitary tumor (GH3) cells. Arch Toxicol, 86(5), 713-723. (SCI, TOXICOLOGY). NSC 98-2320-B-006-027MY3.

24.  Liu YC, Wu PC, Shieh DB, Wu SN (2012, Mar). The effects of magnetite (Fe3O4) nanoparticles on electroporation-induced inward currents in pituitary tumor (GH3) cells and in RAW 264.7 macrophages. Int J Nanomedicine, 7, 1687-1696. (SCI, PHARMACOLOGY & PHARMACY). NSC 98-2320-B-006MY3.

25.  Wu SN, Yeh CC, Wu PY, Huang HC, Tsai ML (2012, Jan). Investigations into the correlation properties of membrane electroporation-induced inward currents: prediction of pore formation. Cell Biochem Biophys, 62(1), 211-220. (SCI, BIOPHYSICS). NSC 98-2320-B-006-027-MY3.

26.  Wang CL, Tsai ML, Wu SN (2012).  Evidence for mitoxantrone-induced block of inwardly rectifying K+ channels expressed in the osteoclast precursor RAW 264.7 cells differentiated with lipopolysaccharide. Cell Physiol Biochem, 30(3), 687-701. (SCI, PHYSIOLOGY). NSC 98-2320-B-006-027-MY3.

27.  Wu SN, Hsu MC, Liao YK, Wu FT, Jong YJ, Lo YC (2012). Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier K+ currents in motor neuonr-like cells. Evid Based Complement Alternat Med, 2012, 148403. (SCI, INTEGRATIVE & COMPLEMENTARY MEDICINE). NSC 98-2320-B-006-027-MY3.

28.  So EC, Wu KC, Liang CH, Chen JY, Wu SN (2011, Nov). Evidence for activation of BKCa channels by a known inhibitor of focal adhesion kinase PF573228. Life Sci, 89(19-20), 691-701. (SCI, MEDICINE, RESEARCH & EXPERIMENTAL). NSC 98-2320-B-006-027-MY3.

29.  Wu SN, Chen BS, Lo YC (2011, Oct). Evidence for aconitine-induced inhibition of delayed rectifier K+ current in Jurkat T-lymphocytes. Toxicology, 289(1):1118. (SCI). NSC 98-2320-B-006-006-MY3.

30.  Wu SN, Wu PY, Tsai ML (2011, May). Characterization of TRPM8-like channels activated by the cooling agent icilin in the macrophage cell line RAW 264.7. J Membr Biol, 241(1):11-20. (SCI). NSC 98-2320-B-006-006-MY3.

31.  Huang CW, Wu YJ, Wu SN (2011, Mar). Modification of activation kinetics of delayed rectifier K+ currents and neuronal excitability by methyl-β-cyclodextrin. Neuroscience, 176, 431-41. (SCI). NSC 98-2314-B-006-042-MY2.

32.  Huang MH, Shen AY, Wang TS, Wu HM, Kang YF, Chen CT, Hsu TI, Chen BS, Wu SN (2011, Feb). Inhibitory action of methadone and its metabolites on ergmediated K+ current in GH pituitary tumor cells. Toxicology, 280(1-2), 1-9. (SCI). NSC 98-2320-B-006-MY3.

33. Wu SN, Huang HC, Yeh CC, Yang WH, Lo YC (2011, Feb). Inhibitory effect of memantine, an NMDA-receptor antagonist, on electroporation-induced inward currents in pituitary GH3 cells. Biochem Biophys Res Commun, 405(3), 508-513. (SCI). NSC 98-2320-B-006-MY3.

34. Wu SN, Lo YC, Shen AY, Chen BS (2011, Feb).  Contribution of non-inactivating Na+ current induced by oxidizing agents to the firing behavior of neuronal action potentials: experimental and theoretical studies from NG108-15 neuronal cells. Chin J Physiol, 54(1):19-29. (SCI). NSC 98-2320-B-006-027-MY3.

35. Wu SN, Yeh CC, Huang HC, Yang WH (2011).  Cholesterol depletion with (2hydroxypropyl)-b-cyclodextrin modifies the gating of membrane electroporationinduced inward current in pituitary tumor GH3 cells: experimental and analytical studies. Cell Physiol Biochem, 28(5), 959-968. (SCI, PHYSIOLOGY). NSC 982320-B-006-027-MY3.

36. Chen BS, Lo YC, Liu YC, Wu SN (2010, Dec).  Effects of transient receptor potential-like current on the firing pattern of action potentials in the Hodgkin Huxley neuron during exposure to sinusoidal external voltage. Chin J Physiol, 53(6), 423-429. (SCI). NSC 94-2320-B-006-019.

37. Chen BS, Lo YC, Peng H, Hsu TI, Wu SN (2010, Oct).  Effects of ranolazine, a novel anti-anginal drug, on ion currents and membrane potential in pituitary tumor GH(3) cells and NG108-15 neuronal cells. J Pharmacol Sci, 110(3), 295305. (SCI). NSC 97-2320-B-006-021.

38. Huang CW, Wu SN, Cheng JT, Tsai JJ, Huang CC (2010, May). Diazoxide reduces status epilepticus neuron damage in diabetes. Neurotox Res, 17(4), 305316. (SCI).

39. Sung RJ, Wu YH, Lai NH, Teng CH, Luo CH, Tien HC, Lo CP, Wu SN (2010, Jan). Beta-adrenergic modulation of arrhythmogenesis and identification of targeted sites of antiarrhythmic therapy in Timothy (LQT8) syndrome: a theoretical study. Am J Physiol Heart Circ Physiol., 298(1), H33-H44. (SCI).

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