NCKU, 生理學科暨研究所

NCKU, 生理學科暨研究所

顏賢章 助理教授

顏賢章(Shian-Jang Yan)助理教授

學經歷:

台灣大學 動物系/生命科學系 學士,1995

美國羅徹斯特大學(University of Rochester)博士,2005

成大生理所 助理教授,2012-迄今

專長學科

細胞及分子生物學,發育生物學,表觀遺傳學

獎勵事項

2009-2012 美國國家衞生硏究院露絲•L基爾希斯國家研究服務獎

 

E-mail

johnyan@mail.ncku.edu.tw

辦公室

82-0732 分機:5437

實驗室

82-0739 分機:5444

嗜好:戶外活動,旅遊,籃球,自行車

研究方向及興趣:

1.   為何不同類型功能的細胞使用相同的基因組涉及表觀遺傳過程(epigenetics process)。這些過程必須受到嚴格的監管,以防止不適當的細胞行為可能導致的人類疾病如癌症和過早老化。

2.   本實驗室利用遺傳、 生化、 分子和細胞生物、 藥理、 和高解析度即時成像技術,並結合果蠅和哺乳動物系統上有效的遺傳學工具,研究抗老及抗癌的機制。

3.   我們的工作側重於信號傳遞 (signaling transduction pathways) 和染色質因子 (chromatin factors 之間的網路 (network),研究表觀遺傳的信號傳遞和染色質因子網路與環境疾病之間的連接。隨著我們更加地瞭解表觀遺傳機制,希望可以提供新的方法及藥物以預防治療癌症和老年疾病。

實驗室成員:

現在成員

博士班:毛彬旭、許文俐、吳博仁、陳昭宜、陳姿羽、張哲維、游佳蓉 

碩士班:賴冠榮、劉嘉瑋、譚永鈺、劉孟璇

大學部:李登宏(醫學)

過去成員

碩士班:張哲維(2017)、陳姿羽(2016)、吳博仁(2015)、陳玉庭(2015)、沈郁家(2015)、黃巧君(2015

大學部:陳俞璇(護理)、李冠儀(醫學)

學生獎勵事項

2017科技部大專生暑期研究計劃(李登宏)

2017成功大學醫學院大生理所英文口頭進度報告第一名 (張哲維)

2016成功大學醫學院學生暑期研究優秀獎(李登宏)

2015科技部大專生暑期研究計劃(陳俞璇)

2015成功大學醫學院學生暑期研究佳作(李冠儀)

2014成功大學醫學院學生暑期研究第二名(陳俞璇)

相關著作(PubMed連結)

1.Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes  under oxidative stress. Wu, C.Y., Hsu, W.L., Tsai, M.H., Liang, J.L., Lu, J.H., Yen, C.J., Yu, H.S., Noda, M., Lu, C.Y., Che,n C.H., Yan, S.J.,* Yoshioka, T. * (2017). Scientific Reports. 7(1):3606. (*Corresponding author)

2.Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy. Mao, B.H., Tsai, J.C., Chen, C.W., Yan, S.J.,* Wang, Y.J*. Nanotoxicology. (2016). 10(8):1021-40. (*corresponding author)

3.Derinat Protects Skin against Ultraviolet-B (UVB)-Induced Cellular Damage. Hsu, W.L., Lu, J.H., Noda, M., Wu, C.Y., Liu, J.D., Sakakibara, M., Tsai, M.H., Yu, H.S., Lin, M.W., Huang, Y.B., Yan, S.J.,*, and Yoshioka, T.* (2015). Molecules. 20(11):20297-311. (*Corresponding author)

4.Tsurumi, A., Dutta, P., Yan, S.J., Sheng, R., and Li, W.X. (2013). Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling. Scientific reports 3, 2894.

5.Gaur, K., Li, J., Wang, D., Dutta, P., Yan, S.J., Tsurumi, A., Land, H., Wu, G., and Li, W.X. (2013). The Birt-Hogg-Dube tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis. Hum Mol Genet 22, 284-299.

6.Yan, S.J., Larson, K., Tsurumi, A., Liu, J., Zhou, J., Gaur, K., Guo, D., Eickbush, T.H., and Li, W.X. (2012). Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS genetics 8, e1002473.

7.Ting, H.J., Yasmin-Karim, S., Yan, S.J., Hsu, J.W., Lin, T.H., Zeng, W., Messing, J., Sheu, T.J., Bao, B.Y., Li, W.X., Messing, E., Lee, Y.F. (2012). A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D. Cancer Res 72, 958-968.

8.Yan, S.J., Lee, Y.F., Ting, H.J., Liu, N.C., Liu S, Lin, S.J., Yeh, S.D., Li, G., and Chang, C. (2012). Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation. Cell Mol Biol Lett. 17(2):309-22.

9.Yan, S.J., Lim, S.J., Shi, S., Dutta, P., and Li, W.X. (2011). Unphosphorylated STAT and heterochromatin protect genome stability. FASEB Journal : official publication of the Federation of American Societies for Experimental Biology 25, 232-241.

10.Yan, S. J.,* and Li, W. X. 2011 Using Drosophila Larval Imaginal Discs to Study Low Dose Radiation-induced Cell Cycle Arrest. Methods Mol Biol 782, 93-103. (*Corresponding author)

11.Yan, S.J., Liu, S., Lee, Y. F., Liu, N. C., Ting, H. J., Chen, L. M. and Chang, C. (2011). The testicular nuclear receptor 4 (TR4) regulates UV-induced responses via Cockayne syndrome B protein-mediated transcription-coupled DNA repair. J Biol Chem. 286, 38103-8. (SCI) (IF=4.573; 61/289, BIOCHEMISTRY & MOLECULAR BIOLOGY)

12.Yan, S. J., Zartman, J. J., Zhang, M., Scott, A., Shvartsman, S. Y. and Li, W. X. (2009). Bistability controls the activation of the EGFR and Dpp pathways in Drosophila wing vein differentiation. Mol Syst Biol 5, 278. Nature/EMBO Molecular Systems Biology cover featured article.

13.Xia, F., Li, J., Hickey, G. W., Tsurumi, A., Larson, K., Guo, D., Yan, S. J., Silver-Morse, L. and Li, W. X. (2008). Raf activation is regulated by Tyrosine 510 phosphorylation in Drosophila. PLoS Biol 6, e128.

14.Shi, S., Larson, K., Guo, D., Lim, S. J., Dutta, P., Yan, S. J. and Li, W. X. (2008). Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability. Nat Cell Biol 10, 489-96.

15.Yan, S. J., Gu, Y., Li, W. X. and Fleming, R. J. (2004). Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development 131, 285-98.

16.Leu, J. H., Yan, S. J., Lee, T. F., Chou, C. M., Chen, S. T., Hwang, P. P., Chou, C. K. and Huang, C. J. (2000). Complete genomic organization and promoter analysis of the round-spotted pufferfish JAK1, JAK2, JAK3, and TYK2 genes. DNA Cell Biol 19, 431-46.

 

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