NCKU, 生理學科暨研究所

NCKU, 生理學科暨研究所

林世杰 專案助理教授

林世杰(Shih-Chieh Lin)助理教授

學經歷:

成大生物系學士,2002

成大醫學院生理所碩士,2004

成大醫學院基醫所博士,2011

加入成功大學教職,2016

 

專長學科    

癌症生物學 分子與細胞生物學, 內分泌學及生物資訊學

獎勵事項

科技部補助千里馬博士後研究 (2 years, 2013~2015)

l   第二十一屆 王民寧 優秀論文獎 (2011)

E-mail

Jaylin@mail.ncku.edu.tw

嗜好:慢跑、單車

研究方向及興趣:

研究興趣:結合分子與細胞生物學以及生物資訊學藉以探討疾

          病生成的原因

研究方向:

1. 探討子宮內膜異位症之致病機轉以及發展新穎之治療方法

 

2. 研究前列腺癌之癌轉移以及雄激素阻斷治療生成抗藥性之機制

實驗室成員:

過去成員

博士班:無

碩士班:無

相關著作(PubMed連結)

1.          Shih-Chieh Lin*, Kuei-Yang Hsiao*, Ning Chang, Pei-Chi Hou, and Shaw-Jenq Tsai. Loss of dual specificity phosphatase-2 promotes angiogenesis and metastasis via upregulation of interleukin-8 in colon cancer. J Pathol. 2016 (major revision) *: Shih-Chieh Lin*, Kuei-Yang Hsiao* contributed equally to this study.

2.          Liu YH, Tsai YS, Lin SC, Liao NS, Jan MS, Liang CT, Hsu SW, Chen WC, Sung JM, Maeda N, Tsai PJ. Quantitative PPARγ expression affects the balance between tolerance and immunity. Sci Rep. 2016 May 25;6:26646. doi: 10.1038/srep26646.

3.          Lin SC, Kao CY, Lee HJ, Creighton CJ, Ittmann MM, Tsai SJ, Tsai SY, Tsai MJ. Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer Nat Commun. 2016 Apr 25;7:11418. doi: 10.1038/ncomms11418.

4.          Tai HC, Tsai PJ, Chen JY, Lai CH, Wang KC, Teng SH, Lin SC, Chang AY, Jiang MJ, Li YH, Wu HL, Maeda N, Tsai YS. PPARγ level contributes to structural integrity and component production of elastic fibers in the aorta Hypertension 2016 Jun;67(6):1298-308. doi: 10.1161/HYPERTENSIONAHA.116.07367. Epub 2016 Apr 4.

5.          Chien CW, Hou PC, Wu HC, Chang YL, Lin SC, Lin SC, Lin BW, Lee JC, Chang YJ, Sun HS, Tsai SJ. Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. Oncogene. 2016 May 2. doi: 10.1038/onc.2016.120. [Epub ahead of print]

6.          Wang L, Xu M, Qin J, Lin SC, Lee HJ, Tsai SY, Tsai MJ.. MPC1, a key gene in cancer metabolism, is regulated by COUP-TFII in human prostate cancer. 2016 Oncotarget 2016 Feb 15. doi: 10.18632/oncotarget.7405. [Epub ahead of print]

7.          Hsiao KY, Lin SC, Wu MH, Tsai SJ. Pathological functions of hypoxia in endometriosis. Front Biosci (Elite Ed). 2015 Jan 1;7:309-21.

8.          Hsiao KY, Chang N, Lin SC, Li YH and Wu MH. Inhibition of dual specificity phosphatase-2 by hypoxia promotes interleukin-8-mediated angiogenesis in endometriosis. Hum Reprod. 2014 Dec;29(12):2747-55.

9.          Qin J, Lee HJ, Wu SP, Lin SC, Lanz RB, Creighton CJ, DeMayo FJ, Tsai SY, Tsai MJ. Androgen deprivation-induced NCoA2 promotes metastatic and castration resistant prostate cancer. J Clin Invest. 2014 Nov;124(11):5013-26

10.      Lin SC*, Li YH*, Wu MH, Chang YF, Lee DK, Tsai SY, Tsai MJ, Tsai SJ. Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. *: Lin SC, Li YH contributed equally to this study. J Clin Endocrinol Metab. 2014 Mar; 99(3):E427-37. doi: 10.1210/jc.2013-3717. Epub 2014 Jan 1

11.      Wang HC, Kooi TK, Kao HY, Lin SC, Tsai SJ. Using positive and negative patterns to extract information from journal articles regarding the regulation of a target gene by a transcription factor. Comput Biol Med. 2013 Dec;43(12):2214-21.

12.      Lin SC*, Wang CC*, Wu MH, Yang SH, Li YH, and Tsai SJ. Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. J Clin Endocrinol Metab. 2012. Aug; 97(8):E1515-23. *: Lin SC, Wang CC contributed equally to this study.

13.      Wu MH*, Lin SC*, Hsiao KY, and Tsai SJ. Hypoxia-inhibited dual specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression. J Pathol. 2011 Nov; 225(3):390-400. doi: 10.1002/path.2963. Epub 2011 Aug 24. *: Wu MH, Lin SC contributed equally to this study.

14.      Lu CW, Lin SC, Chien CW, Lin SC, Lee CT, Lin BW, Lee JC, and Tsai SJ* 2011 Overexpression of pyruvate dehydrogenase kinase-3 increases drug resistance and predicts poor prognosis of colon cancer. Am J Pathol. 2011 Sep;179(3):1405-14. Epub 2011 Jul 18

15.      Lin SC, Chien CW, Lee JC, Yeh YC, Hsu KF, Lai YY, Lin SC, Tsai SJ. Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. J Clin Invest. 2011;121(5):1905–1916

16.      Yeh YC, Wei WC, Wang YK, Lin SC, Sung JM, Tang MJ. Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis. Am J Pathol. 2010 Oct;177(4):1743-54. Epub 2010 Aug 13.

17.      Chien CW, Lin SC, Lai YY, Lin BW, Lin SC, Lee JC, Tsai SJ. Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer. Clin Cancer Res. 2008 Dec 15;14 (24):8043-51. Epub 2008 Dec 10

18.      Lu CW, Lin SC, Chen KF, Lai YY, Tsai SJ. Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J Biol Chem. 2008 Oct 17;283(42):28106-14. (Name changed from SJ Lin to SC Lin)

19.      Wu MH, Chen KF, Lin SJ, Lgu CW, Tsai SJ. Aberrant Expression of Leptin in Human Endometriotic Stromal Cells Is Induced by Elevated Levels of Hypoxia Inducible Factor-1. Am. J. Pathol. 2007 Feb; 170 (2): 590-8

20.    Tsai SJ*, Lin SJ*, Cheng YM, Chen HM, and Wing LYC. Expression and functional analysis of pituitary tumor transforming gene-1 in uterine leiomyomas. J Clin Endocrinol Metab. 2005 Jun; 90(6):3715-23. *:Tsai SJ and Lin SJ contributed equally to this study.